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INFLAMMATION

Dying cell-derived SAM switches off inflammation

The clearance of dying cells by macrophages releases mediators that switch off inflammation. Ampomah et al. reveal how an amino acid derived from apoptotic cargo changes the methylation epigenome of macrophages to take the brakes off an ERK-dependent pathway that terminates inflammatory responses.

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Fig. 1: Role of AC-derived SAM in the phases of efferocytosis.

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Correspondence to Derek W. Gilroy.

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De Maeyer, R.P.H., Gilroy, D.W. Dying cell-derived SAM switches off inflammation. Nat Metab 4, 414–415 (2022). https://doi.org/10.1038/s42255-022-00556-2

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