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The dynamic genetic architecture of early childhood BMI

The genetic architecture of polygenic childhood obesity remains poorly understood. New work characterizes the dynamic genetic architecture of childhood BMI during the first 8 years of life by identifying genetic loci involved in the leptin–melanocortin pathway.

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Fig. 1: Genetic architecture of childhood BMI exhibits dynamic changes over early childhood.


  1. Afshin, A. et al. N. Engl. J. Med. 377, 13–27 (2017).

    Article  Google Scholar 

  2. Geserick, M. et al. N. Engl. J. Med. 379, 1303–1312 (2018).

    Article  Google Scholar 

  3. The, N. S., Suchindran, C., North, K. E., Popkin, B. M. & Gordon-Larsen, P. J. Am. Med. Assoc. 304, 2042–2047 (2010).

    Article  CAS  Google Scholar 

  4. Must, A. & McKeown, N. M. The disease burden associated with overweight and obesity. in Endotext (eds Feingold, K. R. et al.) (, Inc., 2000).

  5. Yengo, L. et al. Hum. Mol. Genet. 27, 3641–3649 (2018).

    Article  CAS  Google Scholar 

  6. Geets, E., Meuwissen, M. E. C. & Van Hul, W. Clin. Genet. 95, 23–40 (2019).

    Article  CAS  Google Scholar 

  7. Chung, W. K. Pediatr. Blood Cancer 58, 122–128 (2012).

    Article  Google Scholar 

  8. Helgeland, Ø. et al. Nat. Metab. (2022).

  9. Helgeland, Ø. et al. Nat. Commun. 10, 4448 (2019).

    Article  Google Scholar 

  10. Couto Alves, A. et al. Sci. Adv. 5, eaaw3095 (2019).

    Article  Google Scholar 

  11. Warrington, N. M. et al. Nat. Genet. 51, 804–814 (2019).

    Article  CAS  Google Scholar 

  12. Yeo, G. S. H. et al. Mol. Metab. 48, 101206 (2021).

    Article  CAS  Google Scholar 

  13. González-García, I., Milbank, E., Diéguez, C., López, M. & Contreras, C. Int. J. Mol. Sci. 20, 3445 (2019).

    Article  Google Scholar 

  14. Brown, T. et al. Cochrane Database Syst. Rev. 7, CD001871 (2019).

    PubMed  Google Scholar 

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The authors thank Xinruo Zhang and Penny Gordon-Larsen for their thoughtful comments on drafts of this work. C.G.D. is supported by R01HL147853. K.E.N. is supported by R01HL142302, R01HL151152, R01 DK122503, R01HD057194, R01HG010297 and R01HL143885.

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Correspondence to Kari E. North.

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Downie, C.G., North, K.E. The dynamic genetic architecture of early childhood BMI. Nat Metab 4, 308–309 (2022).

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