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The dynamic genetic architecture of early childhood BMI

The genetic architecture of polygenic childhood obesity remains poorly understood. New work characterizes the dynamic genetic architecture of childhood BMI during the first 8 years of life by identifying genetic loci involved in the leptin–melanocortin pathway.

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Fig. 1: Genetic architecture of childhood BMI exhibits dynamic changes over early childhood.

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Acknowledgements

The authors thank Xinruo Zhang and Penny Gordon-Larsen for their thoughtful comments on drafts of this work. C.G.D. is supported by R01HL147853. K.E.N. is supported by R01HL142302, R01HL151152, R01 DK122503, R01HD057194, R01HG010297 and R01HL143885.

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Correspondence to Kari E. North.

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Downie, C.G., North, K.E. The dynamic genetic architecture of early childhood BMI. Nat Metab 4, 308–309 (2022). https://doi.org/10.1038/s42255-022-00546-4

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