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The Bacillus subtilis glutamate anti-metabolon

Enzyme–enzyme interactions are largely assumed to act co-operatively to render biochemical pathways more efficient. However, under stress the glutamate synthase of B. subtilis does the exact opposite: it inhibits glutamate degradation by sterically hindering the activity of glutamate dehydrogenase.

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Fig. 1: Metabolic regulation by enzyme–enzyme assembly.


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Correspondence to Alisdair R. Fernie.

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Fernie, A.R., Zhang, Y. The Bacillus subtilis glutamate anti-metabolon. Nat Metab 4, 161–162 (2022).

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