Enzyme–enzyme interactions are largely assumed to act co-operatively to render biochemical pathways more efficient. However, under stress the glutamate synthase of B. subtilis does the exact opposite: it inhibits glutamate degradation by sterically hindering the activity of glutamate dehydrogenase.
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References
Metallo, C. M. & Vander Heiden, M. G. Mol. Cell 49, 388–398 (2013).
Srere, P. A. Trends Biochem. Sci. 10, 109–110 (1985).
Sweetlove, L. J. & Fernie, A. R. Nat. Commun. 9, 2136 (2018).
Zhang, Y. & Fernie, A. R. Plant Commun. 2, 100081 (2020).
Jayaraman, V. et al. Nat. Chem. Biol. (2021).
Huergo, L. F. & Dixon, R. Microbiol. Mol. Biol. Rev. 79, 419–435 (2015).
Messenguy, F. & Wiame, J. FEBS Lett. 3, 47–49 (1969).
Yip, K. M., Fischer, N., Paknia, E., Chari, A. & Stark, H. Nature 587, 157–161 (2020).
Jumper, J. et al. Nature 596, 583–589 (2021).
Hartmann, M.D. Nat. Chem. Biol. https://doi.org/10.1038/s41589-021-00937-w (2021).
Zhang, Y. et al. Nat. Commun. 11, 4509 (2020).
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Fernie, A.R., Zhang, Y. The Bacillus subtilis glutamate anti-metabolon. Nat Metab 4, 161–162 (2022). https://doi.org/10.1038/s42255-022-00534-8
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DOI: https://doi.org/10.1038/s42255-022-00534-8