GAPDH is highly sensitive to oxidation by reactive oxygen species, but how exactly its oxidation alters carbon flux is not known. Talwar et al. demonstrate that oxidative inactivation of GAPDH is required for maximal pentose phosphate pathway flux to support NADPH generation during oxidative stress.
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Change history
14 April 2023
In the version of this article initially published, there were errors in cited research names, where the three instances of Talwar et al. originally referred to Rechmann et al.; the updates are made in the HTML and PDF versions of the article.
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Torrente, L., DeNicola, G.M. GAPDH redox redux—rewiring pentose phosphate flux. Nat Metab 5, 538–539 (2023). https://doi.org/10.1038/s42255-021-00523-3
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DOI: https://doi.org/10.1038/s42255-021-00523-3
