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HDAC6 inhibition overcomes leptin resistance in obesity

Obesity is commonly associated with leptin resistance. Inhibition of HDAC6 in adipose tissue of mice with diet-induced obesity produces a protein factor that augments leptin’s ability to reduce feeding and body weight, and improve glucose tolerance. HDAC6 inhibition acts as a novel treatment for obesity by ameliorating leptin resistance.

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Fig. 1: Interaction of HDAC6 inhibition and leptin signaling.

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Correspondence to Rexford S. Ahima.

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Ahima, R.S. HDAC6 inhibition overcomes leptin resistance in obesity. Nat Metab 4, 11–12 (2022). https://doi.org/10.1038/s42255-021-00500-w

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