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A microbial metabolite linked to fat accumulation

Whether and how host energy metabolism can be controlled by commensal microorganisms remains controversial. New work shows that the microbe-derived metabolite δ-valerobetaine contributes to obesity and hepatic steatosis by modulating mitochondrial fatty acid oxidation and increasing lipid storage in the adipose tissue and liver.

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Fig. 1: A microbial metabolite that alters host metabolism by promoting adiposity.


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Correspondence to Jane F. Ferguson.

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Ferguson, J.F. A microbial metabolite linked to fat accumulation. Nat Metab 3, 1594–1595 (2021).

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