Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

NUTRITION

Periodic fasting prevents fat penalties in females

The fasting-mimicking diet is a five-day cycle of near total fasting each month that extends healthspan in male mice. In this issue of Nature Metabolism, Mishra et al. demonstrate life-extending and cardioprotective benefits of the fasting-mimicking diet in middle-aged female mice that are consuming a high-fat diet.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Fasting-mimicking diet extends life and health span in female mice that are fed a high fat diet.

References

  1. Mitchell, S. J. et al. Cell Metab. 29, 221–228.e3 (2019).

    Article  CAS  Google Scholar 

  2. Liu, K., Liu, B. & Heilbronn, L. K. Physiol. Behav. 218, 112827 (2020).

    Article  CAS  Google Scholar 

  3. Brandhorst, S. et al. Cell Metab. 22, 86–99 (2015).

    Article  CAS  Google Scholar 

  4. Mishra et al. Nat. Metab. https://doi.org/10.1038/s42255-021-00469-6 (2021)

  5. Liu, B., Page, A. J., Hutchison, A. T., Wittert, G. A. & Heilbronn, L. K. Nutrition 66, 38–43 (2019).

    Article  CAS  Google Scholar 

  6. Hutchison, A. T. et al. Obesity (Silver Spring) 27, 50–58 (2019).

    Article  CAS  Google Scholar 

  7. Huang, J. et al. JAMA Intern. Med. 180, 1173–1184 (2020).

    Article  CAS  Google Scholar 

  8. Wu, Y. et al. Cell Metab. 33, 888–904.e6 (2021).

    Article  CAS  Google Scholar 

  9. Yu, D. et al. Cell Metab. 33, 905–922.e6 (2021).

    Article  CAS  Google Scholar 

  10. Lam, Y. Y., Ghosh, S., Civitarese, A. E. & Ravussin, E. J. Gerontol. A Biol. Sci. Med. Sci. 71, 1258–1265 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Leonie K. Heilbronn.

Ethics declarations

Competing interests

The author declares no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Heilbronn, L.K. Periodic fasting prevents fat penalties in females. Nat Metab 3, 1282–1283 (2021). https://doi.org/10.1038/s42255-021-00472-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42255-021-00472-x

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing