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NEUROENDOCRINOLOGY

A blood-to-brain delivery system to treat obesity

Nature Metabolism volume 3, pages 1288–1289 (2021)Cite this article

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Small extracellular vesicles (SEVs) can be used for the selective delivery of therapeutic agents from the blood to the brain. Milbank et al. make use of SEVs to selectively target neurons in the ventromedial hypothalamus of mice, extending this exciting approach to potential applications for the treatment of obesity.

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Fig. 1: Peripherally administered SEVs reach the VMH and trigger sympathetic outflow that leads to body-weight loss.

References

  1. Milbank, E. et al. Nat. Metab. https://doi.org/10.1038/s42255-021-00467-8 (2021).

    Article  Google Scholar 

  2. Choi, Y. H., Fujikawa, T., Lee, J., Reuter, A. & Kim, K. W. Front. Neurosci. 7, 71 (2013).

    PubMed  PubMed Central  Google Scholar 

  3. Alvarez-Erviti, L. et al. Nat. Biotechnol. 29, 341–345 (2011).

    Article  CAS  Google Scholar 

  4. Fernández-Verdejo, R., Marlatt, K. L., Ravussin, E. & Galgani, J. E. Mol. Aspects Med. 68, 82–89 (2019).

    Article  Google Scholar 

  5. Enerbäck, S. Cell Metab. 11, 248–252 (2010).

    Article  Google Scholar 

  6. Feldmann, H. M., Golozoubova, V., Cannon, B. & Nedergaard, J. Cell Metab. 9, 203–209 (2009).

    Article  CAS  Google Scholar 

  7. Cypess, A. M. et al. Cell Metab. 21, 33–38 (2015).

    Article  CAS  Google Scholar 

  8. Khodai, T. & Luckman, S. M. Endocrinology 162, bqab141 (2021).

    Article  Google Scholar 

  9. Xu, Y. et al. Cell Metab. 14, 453–465 (2011).

    Article  CAS  Google Scholar 

  10. Morrison, S. F. & Madden, C. J. Compr. Physiol. 4, 1677–1713 (2014).

    Article  Google Scholar 

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Acknowledgements

This work was supported by National Institutes of Health NIDDK grant R01 DK112198 (to C.J.M.). We thank S. Morrison for critical reading of this work.

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Authors and Affiliations

  1. Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, USA

    Clarissa M. D. Mota & Christopher J. Madden

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  1. Clarissa M. D. Mota
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  2. Christopher J. Madden
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Correspondence to Christopher J. Madden.

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The authors declare no competing interests.

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Mota, C.M.D., Madden, C.J. A blood-to-brain delivery system to treat obesity. Nat Metab 3, 1288–1289 (2021). https://doi.org/10.1038/s42255-021-00463-y

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