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ATHEROSCLEROSIS

Glutamine gluttony of efferocytes

Dysfunctional efferocytosis impairs clearance of apoptotic cells in disease. A new study shows that glutamine catabolism supports efficient apoptotic cell efferocytosis via non-canonical glutamine transamination but not canonical GLUD1-dependent α-ketoglutarate production, in a process that may operate in human atherosclerosis.

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Fig. 1: Reparative macrophages bypass the canonical glutamine metabolism pathway to potentiate efferocytosis.

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Correspondence to Alison Jaccard or Ping-Chih Ho.

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Jaccard, A., Li, X. & Ho, PC. Glutamine gluttony of efferocytes. Nat Metab 3, 1280–1281 (2021). https://doi.org/10.1038/s42255-021-00462-z

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