Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


MIC60 relays oxidation to block mitophagy

Clearance of dMiro from the outer mitochondrial membrane is a prerequisite for mitophagy of dysfunctional mitochondria. Li et al. find that oxidative stress stabilizes dMiro via its interaction with dMIC60. Dissociating this complex by genetic or pharmacologic interventions counteracts neurological aging in flies.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Oxidation of dMIC60 controls dMiro-dependent mitophagy.


  1. Li, L. W., X. Nat. Metab. (2021).

  2. Stephan, T. et al. EMBO J. 39, e104105 (2020).

    CAS  Article  Google Scholar 

  3. von der Malsburg, K. et al. Dev. Cell 21, 694–707 (2011).

    Article  Google Scholar 

  4. Eramo, M. J., Lisnyak, V., Formosa, L. E. & Ryan, M. T. J. Biochem. 167, 243–255 (2020).

    CAS  Article  Google Scholar 

  5. Topf, U. et al. Nat. Commun. 9, 324 (2018).

    Article  Google Scholar 

  6. Mattie, S., Riemer, J., Wideman, J. G. & McBride, H. M. J. Cell Biol. 217, 507–515 (2018).

    CAS  Article  Google Scholar 

  7. Bohovych, I., Dietz, J. V., Swenson, S., Zahayko, N. & Khalimonchuk, O. Antioxid. Redox Signal. 31, 429–443 (2019).

    CAS  Article  Google Scholar 

  8. López-Doménech, G. et al. EMBO J. 37, 321–336 (2018).

    Article  Google Scholar 

  9. Nguyen, T. T. et al. Proc. Natl Acad. Sci. USA 111, E3631–E3640 (2014).

    CAS  Article  Google Scholar 

  10. Hsieh, C. H. et al. Cell Metab. 30, 1131–1140.e7 (2019).

    CAS  Article  Google Scholar 

Download references


Writing of this article was founded by the “Regenerative Mechanisms for Health” project MAB/2017/2 carried out within the International Research Agendas programme of the Foundation for Polish Science co-financed by the European Union under the European Regional Development Fund and was supported by an OPUS grant of National Science Centre, Poland, 2019/35/B/NZ3/04095.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Michał Wasilewski.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Wasilewski, M., Chacinska, A. MIC60 relays oxidation to block mitophagy. Nat Metab 3, 1146–1147 (2021).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing