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DEVELOPMENTAL BIOLOGY

Oocyte metabolites are heritable factors that drive metabolic reprogramming of the progeny

Nature Metabolism volume 3, pages 1148–1149 (2021)Cite this article

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The maternal diet can impact offspring development, yet the mechanisms responsible for this remain largely unknown. New research shows that oocyte metabolites, specifically NAD+ and the methyl donor S-adenosylmethionine, can mediate the impact of maternal nutrient stress on the progeny through metabolic reprogramming in Drosophila.

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Fig. 1: Oocyte metabolites serve as the potential heritable factors that drive reprogramming of progeny metabolism.

References

  1. Barker, D. J. J. Intern. Med. 261, 412–417 (2007).

    Article  CAS  Google Scholar 

  2. Huypens, P. et al. Nat. Genet. 48, 497–499 (2016).

    Article  CAS  Google Scholar 

  3. Han, L. et al. Nat. Genet. 50, 432–442 (2018).

    Article  CAS  Google Scholar 

  4. Hocaoglu, H. et al. Nat. Metab. https://doi.org/10.1038/s42255-021-00450-3 (2021).

  5. Sieber, M. H., Thomsen, M. B. & Spradling, A. C. Cell 164, 420–432 (2016).

    Article  CAS  Google Scholar 

  6. Lu, C. & Thompson, C. B. Cell Metab. 16, 9–17 (2012).

    Article  CAS  Google Scholar 

  7. Locasale, J. W. Nat. Rev. Cancer 13, 572–583 (2013).

    Article  CAS  Google Scholar 

  8. Li, L. et al. Mol. Cell 80, 525–540 (2020).

    Article  CAS  Google Scholar 

  9. Neri, C. & Edlow, A. G. Cold Spring Harb. Perspect. Med. 6, a026591 (2015).

    Article  Google Scholar 

  10. Luke, B. et al. Hum. Reprod. 26, 245–252 (2011).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China

    Shuai Zhu & Qiang Wang

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  1. Shuai Zhu
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  2. Qiang Wang
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Correspondence to Qiang Wang.

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The authors declare no competing interests.

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Zhu, S., Wang, Q. Oocyte metabolites are heritable factors that drive metabolic reprogramming of the progeny. Nat Metab 3, 1148–1149 (2021). https://doi.org/10.1038/s42255-021-00447-y

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