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ExomiRs at the crossroads—divergent role of exosomal miRNAs in early and chronic obesity

Nature Metabolism volume 3, pages 1137–1138 (2021)Cite this article

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Exosomes mediate endocrine crosstalk between distant organs and contribute to disease development. Here, Ji, Luo et al. report that hepatocyte-derived exosomes exert temporally divergent roles in glucose regulation. Exosomal roles strongly differ between early and chronic obesity and this shift in function likely reflects altered exosomal miRNA cargos.

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Fig. 1: Divergent regulation of glucose metabolism by exomiRs miR-3075 and miR-434.

References

  1. Cheng, N. et al. Trends Biotechnol. 37, 1236–1254 (2019).

    Article  CAS  Google Scholar 

  2. Sun, S. J. et al. Stem Cell Rep. 16, 1662–1673 (2021).

    Article  Google Scholar 

  3. Ying, W. et al. Cell Metab. 33, 781–790.e5 (2021).

    Article  CAS  Google Scholar 

  4. Thomou, T. et al. Nature 542, 450–455 (2017).

    Article  CAS  Google Scholar 

  5. Zhang, Y. et al. Cell Biosci. 9, 19 (2019).

    Article  Google Scholar 

  6. Guay, C. et al. Cell Metab. 29, 348–361.e6 (2019).

    Article  CAS  Google Scholar 

  7. Pan, Y. et al. J. Clin. Invest. 129, 834–849 (2019).

    Article  Google Scholar 

  8. Ji, Y. et al. Nat. Metab. https://doi.org/10.1038/s42255-021-00444-1 (2021).

  9. Zhao, Y. et al. Nat. Commun. 11, 719 (2020).

    Article  CAS  Google Scholar 

  10. Guo, L. et al. J. Biol. Chem. 285, 25438–25447 (2010).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department for Biochemistry and Molecular Biology (BMB), University of Southern Denmark, Odense, Denmark

    Joo Hyun Park & Jan-Wilhelm Kornfeld

  2. ADIPOSIGN Research Center, Odense, Denmark

    Jan-Wilhelm Kornfeld

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  1. Joo Hyun Park
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  2. Jan-Wilhelm Kornfeld
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Correspondence to Jan-Wilhelm Kornfeld.

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The authors declare no competing interests.

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Park, J.H., Kornfeld, JW. ExomiRs at the crossroads—divergent role of exosomal miRNAs in early and chronic obesity. Nat Metab 3, 1137–1138 (2021). https://doi.org/10.1038/s42255-021-00446-z

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