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OBESITY

ExomiRs at the crossroads—divergent role of exosomal miRNAs in early and chronic obesity

Exosomes mediate endocrine crosstalk between distant organs and contribute to disease development. Here, Ji, Luo et al. report that hepatocyte-derived exosomes exert temporally divergent roles in glucose regulation. Exosomal roles strongly differ between early and chronic obesity and this shift in function likely reflects altered exosomal miRNA cargos.

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Fig. 1: Divergent regulation of glucose metabolism by exomiRs miR-3075 and miR-434.

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Correspondence to Jan-Wilhelm Kornfeld.

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Park, J.H., Kornfeld, JW. ExomiRs at the crossroads—divergent role of exosomal miRNAs in early and chronic obesity. Nat Metab 3, 1137–1138 (2021). https://doi.org/10.1038/s42255-021-00446-z

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