When the ability of lymphatic vessels to transport fluid and macromolecules is perturbed, local adipose tissue often expands. Cao et al. identify destabilized, leaky mesenteric lymphatic vessels in obesity and demonstrate that correcting this dysfunction with a lymphatic-targeting drug improves systemic glucose metabolism.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Crewe, C., An, Y. A. & Scherer, P. E. J. Clin. Invest. 127, 74–82 (2017).
Cao, E. et al. Nat. Metab. https://doi.org/10.1038/s42255-021-00457-w (2021).
Cifarelli, V. & Eichmann, A. Cell. Mol. Gastroenterol. Hepatol. 7, 503–513 (2019).
Norden, P. R. & Kume, T. Front. Physiol. 11, 404 (2020).
Jiang, X., Tian, W., Nicolls, M. R. & Rockson, S. G. Front. Physiol. 10, 1402 (2019).
Chakraborty, A. et al. Am. J. Pathol. 189, 924–939 (2019).
Kuan, E. L. et al. J. Immunol. 194, 5200–5210 (2015).
Harvey, N. L. et al. Nat. Genet. 37, 1072–1081 (2005).
Zhang, F. et al. Science 361, 599–603 (2018).
Vishwakarma, N. et al. AAPS PharmSciTech 20, 83 (2019).
The author declares no competing interests.
About this article
Cite this article
Rutkowski, J.M. Fixing lymphatics improves glucose metabolism. Nat Metab 3, 1139–1141 (2021). https://doi.org/10.1038/s42255-021-00442-3