Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

NUTRITION

We are more than what we eat

Nature Metabolism volume 3, pages 1144–1145 (2021)Cite this article

Subjects

When is a calorie not just a calorie? In the current issue of Nature Metabolism, Roy et al. use recombinant inbred strains of mice to investigate the role of genetic background in the response to dietary fat. Notably, both lifespan and weight gain have been found to be highly dependent on genotype, thus highlighting the need for a personalized approach to dietary interventions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Genetic variation promotes a diverse response to high-fat-diet feeding.

References

  1. Roy, S. et al. Nat. Metab. https://doi.org/10.1038/s42255-021-00449-w (2021).

  2. Barrington, W. T. et al. Genetics 208, 399–417 (2018).

    Article  CAS  Google Scholar 

  3. Mitchell, S. J. et al. Cell Metab. 23, 1093–1112 (2016).

    Article  CAS  Google Scholar 

  4. Levine, M. E. et al. Cell Metab. 19, 407–417 (2014).

    Article  CAS  Google Scholar 

  5. Fontana, L. et al. Cell Rep. 16, 520–530 (2016).

    Article  CAS  Google Scholar 

  6. Hall, K. D. et al. Cell Metab. 22, 427–436 (2015).

    Article  CAS  Google Scholar 

  7. Wali, J. A. et al. Nat. Metab. 3, 810–828 (2021).

    Article  CAS  Google Scholar 

  8. Yu, D. et al. Cell Metab. 33, 905–922.e906 (2021).

    Article  CAS  Google Scholar 

  9. Richardson, N. E. et al. Nat. Aging 1, 73–86 (2021).

    Article  Google Scholar 

  10. Solon-Biet, S. M. et al. Nat. Metab. 1, 532–545 (2019).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

C.L.G. is supported by a postdoctoral fellowship from the Glenn Foundation for Medical Research. D.W.L. is supported in part by the National Institute on Aging (AG056771, AG062328 and AG061635) and the US Department of Veterans Affairs (I01-BX004031). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This work does not represent the views of the Department of Veterans Affairs or the United States Government.

Author information

Authors and Affiliations

  1. William S. Middleton Memorial Veterans Hospital, Madison, WI, USA

    Cara L. Green & Dudley W. Lamming

  2. Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA

    Cara L. Green & Dudley W. Lamming

Authors
  1. Cara L. Green
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dudley W. Lamming
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dudley W. Lamming.

Ethics declarations

Competing interests

D.W.L. has received funding from, and is a scientific advisory board member of, Aeovian Pharmaceuticals, which seeks to develop novel, selective mTOR inhibitors for the treatment of various diseases. C.L.G. declares no conflicts of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Green, C.L., Lamming, D.W. We are more than what we eat. Nat Metab 3, 1144–1145 (2021). https://doi.org/10.1038/s42255-021-00434-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42255-021-00434-3

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing