Diabetes therapeutic approaches continue to expand and to be refined. As the field moves toward more intensive insulin- and cell-based therapies, care must be taken to mimic healthy physiological insulin dynamics and avoid hyperinsulinemia, with its deleterious downstream complications.
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We thank many colleagues, including J. Kushner, F. Lynn and T. Kieffer, for illuminating discussions on this topic over the years. We thank all of the authors whose work has inspired us.
The authors declare no competing interests.
Peer review information Nature Metabolism thanks the anonymous reviewers for their contribution to the peer review of this work.
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Kolic, J., Johnson, J.D. Promises and pitfalls of beta cell–replacement therapies. Nat Metab 3, 1036–1037 (2021). https://doi.org/10.1038/s42255-021-00433-4