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A wild approach to obesity prevention

Obesity is a growing public-health problem that has been linked to lifestyle changes affecting the diet, which in turn may lead to changes in the commensal microbiota. Hild et al. show that mice colonized with microbiota derived from wild-caught mice are protected against diet-induced obesity, specifically when this microbial colonization occurs early in life.

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Fig. 1: Wildling microbiota prevents diet-induced obesity and related pathologies when introduced early in life.


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We thank R. Patry for discussion and review in preparation of the article.

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Correspondence to Cathryn R. Nagler.

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C.R.N. is the president and cofounder of ClostraBio, Inc. L.A.H. declares no competing interests.

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Hesser, L.A., Nagler, C.R. A wild approach to obesity prevention. Nat Metab 3, 1038–1039 (2021).

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