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There is more than one way to reach type 2 diabetes

The molecular pathophysiology of diabetes in pancreatic islets remains largely a poorly understood ‘black box’ because of the inaccessibility of pancreatic tissue from living humans for molecular analysis. Wigger et al. now explore the transcriptional and proteomic profiles of pancreatic islet sections from people whose glucose tolerance was defined before pancreatic surgery during which a small portion of their pancreata became available for study.

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Fig. 1: An overview of human pancreas procurement and islet isolation for assays that can be deployed to create an atlas of the pancreas in health and disease.


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Correspondence to Anna L. Gloyn.

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A.L.G.’s spouse is an employee of Genentech and holds stock options in Roche. A.C.P. declares no conflicts of interest.

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Gloyn, A.L., Powers, A.C. There is more than one way to reach type 2 diabetes. Nat Metab 3, 894–895 (2021).

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