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TiPpIng the balance in histone acetylation

Nutrient availability and the cell cycle are known to affect chromatin accessibility. A fundamental question is which mechanisms are involved in connecting nutrient levels, the cell cycle and chromatin regulation. In this issue, Zhang et al. reveal a signalling cascade whereby nutrient-sensing mTORC1 activates the cell-cycle regulator CDK2, thus leading to nuclear translocation of the metabolic enzyme triosephosphate isomerase 1 (TPI1). In the nucleus, TPI1 alters the levels of acetate and global histone acetylation through the metabolite dihydroxyacetone phosphate.

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Fig. 1: A novel signalling–metabolic–epigenetic axis.


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Correspondence to Raul Mostoslavsky.

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Roach, L., Mostoslavsky, R. TiPpIng the balance in histone acetylation. Nat Metab 3, 729–731 (2021).

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