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Mitochondrial NADPH is a pro at Pro synthesis

Redox cofactors are essential for the metabolic reactions that support cell proliferation. NADPH is important both to combat oxidative stress and to facilitate reductive reactions in biosynthesis. In this issue, Tran et al. find that the enzyme that produces mitochondrial NADPH is critical in enabling proline synthesis to support cell proliferation when environmental proline is limited.

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Fig. 1: NADK2-mediated mitochondrial NADPH production is required for proline synthesis in low-proline environments.


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Corresponding author

Correspondence to Matthew G. Vander Heiden.

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Competing interests

M.G.V.H. is a scientific advisory board member for Agios Pharmaceuticals, Aeglea Biotherapeutics, iTeos Therapeutics, Faeth Therapeutics and Auron Therapeutics.

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Diehl, F.F., Vander Heiden, M.G. Mitochondrial NADPH is a pro at Pro synthesis. Nat Metab 3, 453–455 (2021).

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