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I’ve got you under my skin

Islet of Langerhans transplantation as a cell therapy for type 1 diabetes faces obstacles that have prevented full and lasting engraftment in the liver, the currently preferred implantation site in clinical practice. Yu and colleagues circumvent these issues and achieve stable diabetes reversal by transplanting islets encapsulated in a simple collagen-based matrix into the more accessible subcutaneous space.

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Fig. 1: Transplantation of islets of Langerhans in the subcutaneous site: how it works and how it can develop.


  1. Harlan, D. M., Kenyon, N. S., Korsgren, O. & Roep, B. O. Diabetes 58, 2175–2184 (2009).

    Article  CAS  Google Scholar 

  2. Barton, F. B. et al. Diabetes Care 35, 1436–1445 (2012).

    Article  CAS  Google Scholar 

  3. Pepper, A. R., Bruni, A. & Shapiro, A. M. J. Curr. Opin. Organ Transplant. 23, 428–439 (2018).

    Article  Google Scholar 

  4. Sakata, N. et al. Diabetes Metab. Res. Rev. 30, 1–10 (2014).

    Article  Google Scholar 

  5. Yu, M. et al. Nat. Metab. (2020).

  6. Riopel, M. & Wang, N. Front. Biosci. (Landmark Ed) 19, 77–90 (2014).

    Article  Google Scholar 

  7. Stephens, C. H. et al. Am. J. Physiol. Endocrinol. Metab. (2020).

  8. Berney, T. & Berishvili, E. Transplantation 99, 2241–2242 (2015).

    Article  Google Scholar 

  9. Hu, S. & de Vos, P. Front. Bioeng. Biotechnol. 7, 134 (2019).

    Article  Google Scholar 

  10. Papas, K. K., De Leon, H., Suszynski, T. M. & Johnson, R. C. Adv. Drug Deliv. Rev. 139, 139–156 (2019).

    Article  CAS  Google Scholar 

  11. Lebreton, F. et al. Am. J. Transplant. 20, 1551–1561 (2020).

    Article  CAS  Google Scholar 

  12. Lebreton, F. et al. Nat. Commun. 10, 4491 (2019).

    Article  CAS  Google Scholar 

  13. Odorico, J. et al. Transplantation 102, 1223–1229 (2018).

    Article  Google Scholar 

  14. Iacovacci, V., Ricotti, L., Menciassi, A. & Dario, P. Biochem. Pharmacol. 100, 12–27 (2016).

    Article  CAS  Google Scholar 

Download references


This work is supported by grants from the Swiss National Science Foundation (grant 310030_173138), the European Foundation for the Study of Diabetes (EFSD), the European Commission (Horizon 2020 Framework Program; VANGUARD grant 874700), the Juvenile Diabetes Research Foundation (JDRF; grant 3-SRA-2020-926-S-B) and the Shota Rustaveli National Science Foundation (grant FR-19-19760).

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Both authors contributed equally to the writing of the manuscript.

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Correspondence to Thierry Berney.

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The authors declare no competing interests.

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Berney, T., Berishvili, E. I’ve got you under my skin. Nat Metab 2, 993–994 (2020).

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