Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

ENERGY HOMEOSTASIS

Seeing the forest for the trees in obesity

GABA-expressing neurons in the arcuate nucleus of the hypothalamus regulate obesity in mice. A recent study indicates the importance of unexamined cell types.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Cell-type hierarchies in the ARC.

References

  1. Cowley, M. A. et al. Nature 411, 480–484 (2001).

    Article  CAS  Google Scholar 

  2. Zhu, C. et al. Nat. Metab. https://doi.org/10.1038/s42255-020-0229-2 (2020).

  3. Aponte, Y., Atasoy, D. & Sternson, S. M. Nat. Neurosci. 14, 351–355 (2010).

    Article  Google Scholar 

  4. Krashes, M. J. et al. J. Clin. Invest 121, 1424–1428 (2011).

    Article  CAS  Google Scholar 

  5. Denis, R. G. et al. Cell Metab. 22, 646–657 (2015).

    Article  CAS  Google Scholar 

  6. Vong, L. et al. Neuron 71, 142–154 (2011).

    Article  CAS  Google Scholar 

  7. Xu, J. et al. Nature 556, 505–509 (2018).

    Article  CAS  Google Scholar 

  8. Zhang, X. & van den Pol, A. N. Nat. Neurosci. 19, 1341–1347 (2016).

    Article  CAS  Google Scholar 

  9. Campbell, J. N. et al. Nat. Neurosci. 20, 484–496 (2017).

    Article  CAS  Google Scholar 

  10. Fenselau, H. et al. Nat. Neurosci. 20, 42–51 (2017).

    Article  CAS  Google Scholar 

  11. Luquet, S., Perez, F. A., Hnasko, T. S. & Palmiter, R. D. Science 310, 683–685 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Scott M. Sternson.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sternson, S.M. Seeing the forest for the trees in obesity. Nat Metab 2, 661–662 (2020). https://doi.org/10.1038/s42255-020-0259-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42255-020-0259-9

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing