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Caught in the genetic network: a novel regulator of lipid metabolism

Genetic-interaction mapping and co-essentiality analyses in human cells reveal the orphan gene C12orf49 (also known as SPRING1) as a novel regulator of lipid-metabolism homeostasis.

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Fig. 1: The genetic interactions and co-essentiality networks of C12orf49 reflect its role in the SREBP pathway.


  1. Robinson, J. L. et al. Sci. Signal. 13, eaaz1482 (2020).

    Article  CAS  Google Scholar 

  2. Aregger, M. et al. Nat. Metab. (2020).

  3. Bayraktar, E. C. et al. Nat. Metab. (2020).

  4. Costanzo, M. et al. Cell 177, 85–100 (2019).

    Article  CAS  Google Scholar 

  5. Horton, J. D., Goldstein, J. L. & Brown, M. S. J. Clin. Invest. 109, 1125–1131 (2002).

    Article  CAS  Google Scholar 

  6. Boyle, E. A., Pritchard, J. K. & Greenleaf, W. J. Mol. Syst. Biol. 14, e8594 (2018).

    Article  Google Scholar 

  7. Kim, E. et al. Life Sci. Alliance 2, e201800278 (2019).

    Article  Google Scholar 

  8. Loregger, A. et al. Nat. Commun. 11, 1128 (2020).

    Article  CAS  Google Scholar 

  9. Klarin, D. et al. Nat. Genet. 50, 1514–1523 (2018).

    Article  CAS  Google Scholar 

  10. Angeles, T. S. & Hudkins, R. L. Expert Opin. Drug Discov. 11, 1187–1199 (2016).

    Article  CAS  Google Scholar 

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Correspondence to Enrico Girardi or Giulio Superti-Furga.

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Girardi, E., Superti-Furga, G. Caught in the genetic network: a novel regulator of lipid metabolism. Nat Metab 2, 483–484 (2020).

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