Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


A BAD portion of glucose can be good for inflamed beta cells

A Publisher Correction to this article was published on 15 June 2020

This article has been updated

Exposure to high glucose under inflammatory conditions is detrimental to insulin-secreting beta cells in the pancreas. Fu and colleagues describe a metabolic axis that decreases production of the ‘danger molecule’ nitric oxide and improves the survival of beta cells exposed to an inflammatory milieu, thus paving the way to new interventions for diabetes.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The metabolic axis elucidated by Fu and colleagues.

Change history


  1. Dadon, D. et al. Diabetes Obes. Metab. 14(Suppl. 3), 101–108 (2012).

    Article  CAS  Google Scholar 

  2. Donath, M. Y., Dalmas, É., Sauter, N. S. & Böni-Schnetzler, M. Cell Metab. 17, 860–872 (2013).

    Article  CAS  Google Scholar 

  3. Danial, N. N. et al. Nature 424, 952–956 (2003).

    Article  CAS  Google Scholar 

  4. Danial, N. N. et al. Nat. Med. 14, 144–153 (2008).

    Article  CAS  Google Scholar 

  5. Matschinsky, F. M. & Wilson, D. F. Front. Physiol. 10, 148 (2019).

    Article  Google Scholar 

  6. Szlyk, B. et al. Nat. Struct. Mol. Biol. 21, 36–42 (2014).

    Article  CAS  Google Scholar 

  7. Ljubicic, S. et al. Cell Rep. 10, 497–504 (2015).

    Article  CAS  Google Scholar 

  8. Matschinsky, F. M. Nat. Rev. Drug Discov. 8, 399–416 (2009).

    Article  CAS  Google Scholar 

  9. Fu, A. et al. Nat. Metab (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Donath, M. Y., Størling, J., Berchtold, L. A., Billestrup, N. & Mandrup-Poulsen, T. Endocr. Rev 29, 334–350 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Christian Frezza.

Ethics declarations

Competing interests

C.F. is a member of the scientific advisory board of Owlstone Medicals and a scientific advisor of Istesso.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Frezza, C. A BAD portion of glucose can be good for inflamed beta cells. Nat Metab 2, 383–384 (2020).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research