NAD on the rise again

Maintaining cellular NAD levels through supplementation with intermediates of NAD synthesis has considerable health benefits. A new study demonstrates that the reduced form of nicotinamide riboside, NRH, can be converted to NAD in a biosynthetic pathway that involves adenosine kinase, thus strongly boosting NAD levels in cells and tissues.

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Fig. 1: NRH enters NAD synthesis through AK and boosts NAD-dependent metabolism and signalling.


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M.Z. was supported by the Norwegian Research Council and the Norwegian Cancer Society. A.A.N. was supported by the Program for Molecular and Cell Biology and Post-Genomic Technologies of the Russian Academy of Sciences.

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Correspondence to Mathias Ziegler or Andrey A. Nikiforov.

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The authors declare no competing interests.

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Ziegler, M., Nikiforov, A.A. NAD on the rise again. Nat Metab 2, 291–292 (2020).

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