Maintaining cellular NAD levels through supplementation with intermediates of NAD synthesis has considerable health benefits. A new study demonstrates that the reduced form of nicotinamide riboside, NRH, can be converted to NAD in a biosynthetic pathway that involves adenosine kinase, thus strongly boosting NAD levels in cells and tissues.
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Enzymatic synthesis of high-titer nicotinamide mononucleotide with a new nicotinamide riboside kinase and an efficient ATP regeneration system
Bioresources and Bioprocessing Open Access 21 March 2022
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Acknowledgements
M.Z. was supported by the Norwegian Research Council and the Norwegian Cancer Society. A.A.N. was supported by the Program for Molecular and Cell Biology and Post-Genomic Technologies of the Russian Academy of Sciences.
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Ziegler, M., Nikiforov, A.A. NAD on the rise again. Nat Metab 2, 291–292 (2020). https://doi.org/10.1038/s42255-020-0197-6
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DOI: https://doi.org/10.1038/s42255-020-0197-6
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