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References
Kajimura, S. & Spiegelman, B. M. Confounding issues in the ‘humanized’ brown fat of mice. Nat. Metab. https://doi.org/10.1038/s42255-020-0192-y (2020).
de Jong, J. M. A. et al. Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice. Nat. Metab. 1, 830–843 (2019).
Saito, M. et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58, 1526–1531 (2009).
Senn, J. R. et al. Outdoor temperature influences cold induced thermogenesis in humans. Front. Physiol. 9, 1184 (2018).
Fischer, A. W. et al. Leptin raises defended body temperature without activating thermogenesis. Cell Rep. 14, 1621–1631 (2016).
Westerterp, K. R. Exercise, energy expenditure and energy balance, as measured with doubly labelled water. Proc. Nutr. Soc. 77, 4–10 (2018).
Fischer, A. W., Cannon, B. & Nedergaard, J. Optimal housing temperatures for mice to mimic the thermal environment of humans: an experimental study. Mol. Metab. 7, 161–170 (2018).
Wu, J. et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150, 366–376 (2012).
Sharp, L. Z. et al. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS ONE 7, e49452 (2012).
Walden, T. B., Hansen, I. R., Timmons, J. A., Cannon, B. & Nedergaard, J. Recruited vs. nonrecruited molecular signatures of brown, ‘brite,’ and white adipose tissues. Am. J. Physiol. 302, E19–E31 (2012).
Sanchez-Gurmaches, J. & Guertin, D. A. Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed. Nat. Commun. 5, 4099 (2014).
de Jong, J. M., Larsson, O., Cannon, B. & Nedergaard, J. A stringent validation of mouse adipose tissue identity markers. Am. J. Physiol. 308, E1085–E1105 (2015).
Cypess, A. M. et al. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat. Med. 19, 635–639 (2013).
Abreu-Vieira, G. et al. Cidea improves the metabolic profile through expansion of adipose tissue. Nat. Commun. 6, 7433 (2015).
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J.d.J., B.C., J.N., C.W. and N.P. wrote the manuscript.
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de Jong, J.A., Cannon, B., Nedergaard, J. et al. Reply to ‘Confounding issues in the ‘humanized’ brown fat of mice’. Nat Metab 2, 305–306 (2020). https://doi.org/10.1038/s42255-020-0193-x
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DOI: https://doi.org/10.1038/s42255-020-0193-x
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