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A macrophage-derived adipokine supports skeletal muscle regeneration

Macrophages are required for postinjury skeletal muscle regeneration. A new study reveals that proinflammatory macrophages produce meteorin-like, which promotes muscle stem cell expansion through the Stat3–IGF1 axis and then shifts their inflammatory profile to allow return to homeostasis.

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Fig. 1: Macrophage-derived Metrnl promotes skeletal muscle regeneration.


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Correspondence to Bénédicte Chazaud.

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Chazaud, B. A macrophage-derived adipokine supports skeletal muscle regeneration. Nat Metab 2, 213–214 (2020).

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