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Microbial signatures in metabolic tissues: a novel paradigm for obesity and diabetes?

By analysing microbial profiles in three adipose tissue depots and the liver and plasma of morbidly obese individuals, a new study uncovers a unique organ-specific microbial signature, or potential internal ‘tissue microbiota’, in obese people with diabetes.

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Fig. 1: Bacterial compartmentalization in obese and diabetic individuals.


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P.D.C. is a senior research associate at Fonds de la Recherche Scientifique (FRS-FNRS), Belgium. He is supported by the Fonds Baillet Latour (Grant for Medical Research 2015), the Fondsde la Recherche Scientifique (FNRS, FRFS-WELBIO: WELBIO-CR-2019C-02R and EOS program no. 30770923).

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Correspondence to Patrice D. Cani.

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P.D.C. is an inventor in patent applications related to the use of Akkermansia muciniphila and its components in the context of obesity and related disorders. P.D.C. is also a co-founder of A-Mansia Biotech SA. M.V.H. declares no conflicts of interest.

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Cani, P.D., Van Hul, M. Microbial signatures in metabolic tissues: a novel paradigm for obesity and diabetes?. Nat Metab 2, 211–212 (2020).

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