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DIABETES

More is better: combinatorial therapy to restore β-cell function in diabetes

Current pharmacological options for diabetes treatment help patients control blood glucose levels but do not reverse the decline in insulin-secreting β-cells. A new study now shows that a pharmacological combination of insulin and a GLP-1–oestrogen conjugate not only decreases daily insulin requirements but also improves β-cell function.

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Fig. 1: Summary of the steps during loss of β-cell identity, analysed by single-cell RNA-sequencing.

References

  1. Weir, G. C. & Bonner-Weir, S. Diabetes 53(Suppl. 3), S16–S21 (2004).

    CAS  Article  Google Scholar 

  2. Banting, F. G. & Best, C. H. J. Lab. Clin. Med. 7, 251–266 (1922).

    CAS  Google Scholar 

  3. De Jesus, D. F. & Kulkarni, R. N. Mol. Metab. 27S, S42–S48 (2019).

    Article  Google Scholar 

  4. Talchai, C., Xuan, S., Lin, H. V., Sussel, L. & Accili, D. Cell 150, 1223–1234 (2012).

    CAS  Article  Google Scholar 

  5. Rui, J. et al. Cell Metab. 25, 727–738 (2017).

    CAS  Article  Google Scholar 

  6. Dirice, E. et al. Nat. Metab. 1, 509–518 (2019).

    Article  Google Scholar 

  7. Sachs, S. Nat. Metab. https://doi.org/10.1038/s42255-020-0171-3 (2020).

    Article  Google Scholar 

  8. Like, A. A. & Rossini, A. A. Science 193, 415–417 (1976).

    CAS  Article  Google Scholar 

  9. Kulkarni, R. N. et al. Cell 96, 329–339 (1999).

    CAS  Article  Google Scholar 

  10. Le May, C. et al. Proc. Natl Acad. Sci. USA 103, 9232–9237 (2006).

    Article  Google Scholar 

  11. Drucker, D. J., Philippe, J., Mojsov, S., Chick, W. L. & Habener, J. F. Proc. Natl Acad. Sci. USA 84, 3434–3438 (1987).

    CAS  Article  Google Scholar 

  12. Finan, B. et al. Nat. Med. 18, 1847–1856 (2012).

    CAS  Article  Google Scholar 

  13. Bader, E. et al. Nature 535, 430–434 (2016).

    CAS  Article  Google Scholar 

  14. Karakose, E., Ackeifi, C., Wang, P. & Stewart, A. F. Diabetologia 61, 1693–1699 (2018).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Rohit N. Kulkarni.

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De Jesus, D.F., Kulkarni, R.N. More is better: combinatorial therapy to restore β-cell function in diabetes. Nat Metab 2, 130–131 (2020). https://doi.org/10.1038/s42255-020-0176-y

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