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More is better: combinatorial therapy to restore β-cell function in diabetes

Current pharmacological options for diabetes treatment help patients control blood glucose levels but do not reverse the decline in insulin-secreting β-cells. A new study now shows that a pharmacological combination of insulin and a GLP-1–oestrogen conjugate not only decreases daily insulin requirements but also improves β-cell function.

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Fig. 1: Summary of the steps during loss of β-cell identity, analysed by single-cell RNA-sequencing.


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Correspondence to Rohit N. Kulkarni.

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De Jesus, D.F., Kulkarni, R.N. More is better: combinatorial therapy to restore β-cell function in diabetes. Nat Metab 2, 130–131 (2020).

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