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DIABETES

More is better: combinatorial therapy to restore β-cell function in diabetes

Nature Metabolism volume 2, pages 130–131 (2020)Cite this article

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Current pharmacological options for diabetes treatment help patients control blood glucose levels but do not reverse the decline in insulin-secreting β-cells. A new study now shows that a pharmacological combination of insulin and a GLP-1–oestrogen conjugate not only decreases daily insulin requirements but also improves β-cell function.

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Fig. 1: Summary of the steps during loss of β-cell identity, analysed by single-cell RNA-sequencing.

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Authors and Affiliations

  1. Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA

    Dario F. De Jesus & Rohit N. Kulkarni

  2. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Dario F. De Jesus & Rohit N. Kulkarni

  3. Harvard Stem Cell Institute, Harvard University, Boston, MA, USA

    Dario F. De Jesus & Rohit N. Kulkarni

Authors
  1. Dario F. De Jesus
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  2. Rohit N. Kulkarni
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Correspondence to Rohit N. Kulkarni.

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De Jesus, D.F., Kulkarni, R.N. More is better: combinatorial therapy to restore β-cell function in diabetes. Nat Metab 2, 130–131 (2020). https://doi.org/10.1038/s42255-020-0176-y

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