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Liver zonation—a journey through space and time

Liver function depends on the temporal and zonal distribution of complementary metabolic tasks in hepatocytes. A new study by Droin et al. highlights how chronobiology and liver zonation orchestrate liver metabolism at single-cell resolution.

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Fig. 1: Spatiotemporal distribution of hepatic gene expression.


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Correspondence to Jan S. Tchorz.

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The authors declare no competing interests.

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Annunziato, S., Tchorz, J.S. Liver zonation—a journey through space and time. Nat Metab 3, 7–8 (2021).

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