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Loss of gene coordination as a stochastic cause of ageing

Nature Metabolism volume 2, pages 1188–1189 (2020)Cite this article

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A new global measure of cell-to-cell transcriptional variability from single-cell RNA-sequencing data has been developed by Levy et al., on the basis of the transcriptional interrelations between genes. The new variable, termed global coordination level, decreases with age in different organisms and cell types and correlates with high mutational load in cells.

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Fig. 1: How mutation accumulation can lead to GCL decline.

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Authors and Affiliations

  1. Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA

    Jan Vijg

  2. Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Jan Vijg

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  1. Jan Vijg
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Correspondence to Jan Vijg.

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Competing interests

J.V. is a cofounder of and stock holder in SingulOmics, Corp., USA.

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Vijg, J. Loss of gene coordination as a stochastic cause of ageing. Nat Metab 2, 1188–1189 (2020). https://doi.org/10.1038/s42255-020-00295-2

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