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CD38-expressing macrophages drive age-related NAD+ decline

The restoration of the progressive decline in nicotinamide adenine dinucleotide (NAD+) levels mitigates certain age-associated dysfunctions. A fundamental question is how the NAD+-consuming enzyme CD38 decreases NAD+ levels during ageing. Two new studies by Chini et al. and Covarrubias et al. in this issue of Nature Metabolism show that CD38 expression in macrophages induced by senescence-associated inflammation accounts for the age-related decline in NAD+ levels.

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Fig. 1: CD38 induction in M1-like macrophages by senescence-associated inflammation drives age-related NAD+ decline.


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Correspondence to Rugang Zhang.

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Wu, S., Zhang, R. CD38-expressing macrophages drive age-related NAD+ decline. Nat Metab 2, 1186–1187 (2020).

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