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AGEING

CD38-expressing macrophages drive age-related NAD+ decline

The restoration of the progressive decline in nicotinamide adenine dinucleotide (NAD+) levels mitigates certain age-associated dysfunctions. A fundamental question is how the NAD+-consuming enzyme CD38 decreases NAD+ levels during ageing. Two new studies by Chini et al. and Covarrubias et al. in this issue of Nature Metabolism show that CD38 expression in macrophages induced by senescence-associated inflammation accounts for the age-related decline in NAD+ levels.

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Fig. 1: CD38 induction in M1-like macrophages by senescence-associated inflammation drives age-related NAD+ decline.

References

  1. Verdin, E. Science 350, 1208–1213 (2015).

    CAS  Article  Google Scholar 

  2. Katsyuba, E., Romani, M., Hofer, D. & Auwerx, J. Nat Metab 2, 9–31 (2020).

    CAS  Article  Google Scholar 

  3. Zhao, Y. J., Lam, C. M. & Lee, H. C. Sci. Signal. 5, ra67 (2012).

    Article  Google Scholar 

  4. Shrimp, J. H. et al. J. Am. Chem. Soc. 136, 5656–5663 (2014).

    CAS  Article  Google Scholar 

  5. Billington, R. A. et al. Mol. Med. 12, 324–327 (2006).

    CAS  Article  Google Scholar 

  6. De Flora, A., Guida, L., Franco, L. & Zocchi, E. Int. J. Biochem. Cell Biol. 29, 1149–1166 (1997).

    Article  Google Scholar 

  7. Camacho-Pereira, J. et al. Cell Metab. 23, 1127–1139 (2016).

    CAS  Article  Google Scholar 

  8. Tarrago, M. G. et al. Cell Metab. 27, 1081–1095.e1010 (2018).

    CAS  Article  Google Scholar 

  9. Chini, C. C. S. et al. Nat. Metab. https://doi.org/10.1038/s42255-020-00298-z (2020).

  10. Covarrubias, A. J. et al. Nat. Metab. https://doi.org/10.1038/s42255-020-00305-3 (2020).

  11. Amici, S. A. et al. Front Immunol. 9, 1593 (2018).

    Article  Google Scholar 

  12. Coppé, J. P., Desprez, P. Y., Krtolica, A. & Campisi, J. Annu. Rev. Pathol. 5, 99–118 (2010).

    Article  Google Scholar 

  13. van Deursen, J. M. Nature 509, 439–446 (2014).

    Article  Google Scholar 

  14. Xu, M. et al. Nat. Med. 24, 1246–1256 (2018).

    CAS  Article  Google Scholar 

  15. Nacarelli, T. et al. Nat. Cell Biol. 21, 397–407 (2019).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Rugang Zhang.

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Wu, S., Zhang, R. CD38-expressing macrophages drive age-related NAD+ decline. Nat Metab 2, 1186–1187 (2020). https://doi.org/10.1038/s42255-020-00292-5

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