ATHEROSCLEROSIS

Novel mechanistic links between high-protein diets and atherosclerosis

New research in this issue of Nature Metabolism shows how a high-protein diet increases amino acids in blood and atherosclerotic plaques, and in plaque macrophages activates mTOR signalling, suppresses mitophagy and increases apoptosis, thereby exacerbating atherosclerotic-plaque build-up in genetically modified mouse models.

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Fig. 1: The link between high-protein diets and atherosclerosis: what is known and what remains to be addressed.

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Correspondence to Hanrui Zhang or Muredach P. Reilly.

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The authors declare no competing interests.

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Zhang, H., Reilly, M.P. Novel mechanistic links between high-protein diets and atherosclerosis. Nat Metab 2, 7–8 (2020). https://doi.org/10.1038/s42255-019-0163-3

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