New research in this issue of Nature Metabolism shows how a high-protein diet increases amino acids in blood and atherosclerotic plaques, and in plaque macrophages activates mTOR signalling, suppresses mitophagy and increases apoptosis, thereby exacerbating atherosclerotic-plaque build-up in genetically modified mouse models.
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References
Moore, K. J. et al. J. Am. Coll. Cardiol. 72, 2181–2197 (2018).
Hadjiphilippou, S. & Ray, K. K. Circ. Res. 124, 354–363 (2019).
Larsen, T. M. et al. N. Engl. J. Med. 363, 2102–2113 (2010).
Lagiou, P. et al. Br. Med. J. 344, e4026 (2012).
Virtanen, H. E. K. et al. Circ. Heart Fail. 11, e004531 (2018).
Zhang, X. et al. Nat Metab. https://doi.org/10.1038/s42255-019-0162-4 (2019).
Saxton, R. A. & Sabatini, D. M. Cell 168, 960–976 (2017).
Kalaitzidis, D. et al. Cell Stem Cell 11, 429–439 (2012).
McGarrah, R. W., Crown, S. B., Zhang, G. F., Shah, S. H. & Newgard, C. B. Circ. Res. 122, 1238–1258 (2018).
Wang, T. J. et al. Nat. Med. 17, 448–453 (2011).
Holmes, M. V., Ala-Korpela, M. & Smith, G. D. Nat. Rev. Cardiol. 14, 577–590 (2017).
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Zhang, H., Reilly, M.P. Novel mechanistic links between high-protein diets and atherosclerosis. Nat Metab 2, 7–8 (2020). https://doi.org/10.1038/s42255-019-0163-3
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DOI: https://doi.org/10.1038/s42255-019-0163-3
