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Clogging the mitochondrial protein-entry gate promotes obesity

Under a high-fat diet, the amyloid precursor protein, which is involved in the development of Alzheimer’s disease, accumulates at the protein-entry gate of mitochondria in white adipose tissue, thus leading to mitochondrial dysfunction, adipocyte hypertrophy and obesity.

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Fig. 1: Mislocalization of APP to mitochondria in white adipose tissue promotes obesity.

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Correspondence to Thomas Becker.

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Song, J., Becker, T. Clogging the mitochondrial protein-entry gate promotes obesity. Nat Metab 1, 1175–1176 (2019). https://doi.org/10.1038/s42255-019-0155-3

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