Targeting macrophage immunometabolism to prevent atherosclerosis

Di Gioia and colleagues report on how the oxidized phospholipid oxPAPC alters metabolism in macrophages via glutamine and oxaloacetate, thus boosting production of the cytokine IL-1β and promoting atherosclerosis.

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Fig. 1: Macrophage metabolism in response to LPS and oxPAPC.


  1. 1.

    O’Neill, L. A., Kishton, R. J. & Rathmell, J. Nat. Rev. Immunol. 16, 553–565 (2016).

  2. 2.

    O’Neill, L. A. & Pearce, E. J. J. Exp. Med. 213, 15–23 (2016).

  3. 3.

    Hooftman, A. & O’Neill, L. A. J. Trends Immunol. 40, 687–698 (2019).

  4. 4.

    Di Gioia, M. et al Nat. Immunol. (2019).

  5. 5.

    Mills, E. L. et al. Cell 167, 457–470.e13 (2016).

  6. 6.

    Bailey, J. D. et al. Cell Rep. 28, 218–230.e7 (2019).

  7. 7.

    Ridker, P. M. et al. N. Engl. J. Med. 377, 1119–1131 (2017).

  8. 8.

    Jha, A. K. et al. Immunity 42, 419–430 (2015).

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Correspondence to Luke A. J. O’Neill.

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O’Neill, L.A.J. Targeting macrophage immunometabolism to prevent atherosclerosis. Nat Metab 1, 1173–1174 (2019) doi:10.1038/s42255-019-0154-4

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