MACROPHAGE METABOLISM

Targeting macrophage immunometabolism to prevent atherosclerosis

Di Gioia and colleagues report on how the oxidized phospholipid oxPAPC alters metabolism in macrophages via glutamine and oxaloacetate, thus boosting production of the cytokine IL-1β and promoting atherosclerosis.

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Fig. 1: Macrophage metabolism in response to LPS and oxPAPC.

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Correspondence to Luke A. J. O’Neill.

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The author declares no competing interests.

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O’Neill, L.A.J. Targeting macrophage immunometabolism to prevent atherosclerosis. Nat Metab 1, 1173–1174 (2019) doi:10.1038/s42255-019-0154-4

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