Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


Pancreatic islet secretion: gabbling via GABA


A new study by Menegaz et al. in this issue of Nature Metabolism addresses fundamental questions on the acute regulation and role of GABA secretion in pancreatic islets.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Role of β-cell-derived GABA in the coordination of glucagon and insulin secretion in health and in type 2 diabetes.


  1. Rutter, G. A., Pullen, T. J., Hodson, D. J. & Martinez-Sanchez, A. Biochem. J. 466, 202–218 (2015).

    Article  Google Scholar 

  2. Gromada, J., Chabosseau, P. & Rutter, G. A. Nat. Rev. Endocrinol. 14, 694–704 (2018).

    Article  CAS  Google Scholar 

  3. Braun, M. et al. Diabetes 59, 1694–1701 (2010).

    Article  CAS  Google Scholar 

  4. Rorsman, P. et al. Proc. Natl. Acad. Sci. USA 86, 4505–4509 (1989).

    Article  CAS  Google Scholar 

  5. Bailey, S. J., Ravier, M. A. & Rutter, G. A. Diabetes 56, 320–327 (2007).

    Article  CAS  Google Scholar 

  6. Smismans, A., Schuit, F. & Pipeleers, D. Diabetologia 40, 1411–1415 (1997).

    Article  CAS  Google Scholar 

  7. Menegaz, D. et al. Nat. Metab. (2019).

    Article  Google Scholar 

  8. Best, L. & Yates, A. P. Islets 2, 303–307 (2010).

    Article  Google Scholar 

  9. Johnston, N. R. et al. Cell Metab. 24, 389–401 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Guy A. Rutter.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rutter, G.A. Pancreatic islet secretion: gabbling via GABA. Nat Metab 1, 1032–1033 (2019).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing