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CARDIAC BIOLOGY

ABHD5 cleaves HDAC4 to benefit the heart

Nature Metabolism volume 1, pages 1034–1035 (2019)Cite this article

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A study in Nature Metabolism reveals a hitherto-unknown enzymatic and physiological role of ABHD5, which acts as a protease that couples extracellular cues to the epigenome of cardiomyocytes by cleaving histone deacetylase 4 (HDAC4).

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Fig. 1: A signalling pathway for controlling pathological gene expression in the heart.

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Acknowledgements

T.A.M. was supported by the National Institutes of Health through grants HL116848, HL147558, DK119594 and HL127240. J.G.T. was supported by the National Institutes of Health through grant HL147463. T.A.M. and J.G.T. were supported by the American Heart Association (16SFRN31400013).

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  1. Department of Medicine, Division of Cardiology, and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    Joshua G. Travers & Timothy A. McKinsey

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  1. Joshua G. Travers
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  2. Timothy A. McKinsey
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Correspondence to Timothy A. McKinsey.

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Travers, J.G., McKinsey, T.A. ABHD5 cleaves HDAC4 to benefit the heart. Nat Metab 1, 1034–1035 (2019). https://doi.org/10.1038/s42255-019-0141-9

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