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Why we need to curb the emerging worldwide epidemic of nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) has emerged as the most prevalent liver disease worldwide, mainly because of the massive parallel global increase in obesity. Extensive public-health and political efforts will be needed in the near future to counteract this disturbing development.

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References

  1. Estes, C. et al. J. Hepatol. 69, 896–904 (2018).

    Article  Google Scholar 

  2. Haldar, D. et al. J. Hepatol. 71, 313–322 (2019).

    Article  Google Scholar 

  3. Li, Z. et al. J. Gastroenterol. Hepatol. 29, 42–51 (2014).

    Article  CAS  Google Scholar 

  4. Stepanova, M. et al. Clin Gastroenterol Hepatol 15, 759–766.e755 (2017).

    Article  Google Scholar 

  5. Jewell, J. & Sheron, N. Clin. Med. (Lond.) 10, 259–263 (2010).

    Article  Google Scholar 

  6. Clair, H. B. et al. Toxicol. Sci. 164, 39–49 (2018).

    Article  CAS  Google Scholar 

  7. Ryan, D. H. & Yockey, S. R. Curr. Obes. Rep. 6, 187–194 (2017).

    Article  Google Scholar 

  8. Tremmel, M., Gerdtham, U. G., Nilsson, P. M. & Saha, S. Int. J. Environ. Res. Public Health 14, 435 (2017).

    Article  Google Scholar 

  9. Brewis, A. A. Soc. Sci. Med. 118, 152–158 (2014).

    Article  Google Scholar 

  10. Bilger, M., Kruger, E. J. & Finkelstein, E. A. Health Econ. 26, 1052–1066 (2017).

    Article  Google Scholar 

  11. Lazarus, J. V. et al. J. Hepatol. https://doi.org/10.1016/j.jhep.2019.08.027 (2019).

  12. Barata Cavalcanti, O. World Obesity https://s3-eu-west-1.amazonaws.com/wof-files/LATAM_presentation_Regional_Dialogue__Barata_cavalcanti_FINAL.pdf (2019).

  13. Williams, R. et al. Lancet 392, 2398–2412 (2018).

    Article  Google Scholar 

  14. European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) & European Association for the Study of Obesity (EASO). J. Hepatol. 64, 1388–1402 (2016).

  15. Ananthapavan, J., Sacks, G., Moodie, M. & Carter, R. Int. J. Environ. Res. Public Health 11, 4007–4025 (2014).

    Article  Google Scholar 

  16. Williams, R. et al. Lancet 384, 1953–1997 (2014).

    Article  Google Scholar 

  17. Anderson, E. L. et al. PLoS One 10, e0140908 (2015).

    Article  Google Scholar 

  18. O’Reilly, J. R. & Reynolds, R. M. Clin. Endocrinol. 78, 9–16 (2013).

    Article  Google Scholar 

  19. Wesolowski, S. R., Kasmi, K. C., Jonscher, K. R. & Friedman, J. E. Nat. Rev. Gastroenterol. Hepatol. 14, 81–96 (2017).

    Article  CAS  Google Scholar 

  20. Skouteris, H. et al. Front. Endocrinol. (Lausanne) 10, 163 (2019).

    Article  Google Scholar 

Download references

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All authors researched data for this article, and wrote, reviewed and edited the manuscript.

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Correspondence to Anna Mae Diehl or Herbert Tilg.

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Diehl, A.M., Farpour-Lambert, N.J., Zhao, L. et al. Why we need to curb the emerging worldwide epidemic of nonalcoholic fatty liver disease. Nat Metab 1, 1027–1029 (2019). https://doi.org/10.1038/s42255-019-0140-x

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