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AGEING

Age is in the nucleus

Nature Metabolism volume 1, pages 931–932 (2019)Cite this article

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Nuclear DNA damage has detrimental effects on cellular homoeostasis and accelerates the ageing process. A new study causally links error-prone mitochondrial replication to increased nuclear DNA damage, thus suggesting that the hallmarks of ageing are associated with nuclear genome instability, a potential unifying denominator in the ageing process.

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Fig. 1: Nuclear DNA damage integrates the multiple hallmarks of ageing.

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Authors and Affiliations

  1. Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Cologne, Germany

    Björn Schumacher

  2. Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany

    Björn Schumacher

  3. Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA

    Jan Vijg

  4. Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Jan Vijg

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  1. Björn Schumacher
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  2. Jan Vijg
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Correspondence to Björn Schumacher or Jan Vijg.

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The authors declare no competing interests.

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Schumacher, B., Vijg, J. Age is in the nucleus. Nat Metab 1, 931–932 (2019). https://doi.org/10.1038/s42255-019-0125-9

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