Age is in the nucleus

Nuclear DNA damage has detrimental effects on cellular homoeostasis and accelerates the ageing process. A new study causally links error-prone mitochondrial replication to increased nuclear DNA damage, thus suggesting that the hallmarks of ageing are associated with nuclear genome instability, a potential unifying denominator in the ageing process.

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Fig. 1: Nuclear DNA damage integrates the multiple hallmarks of ageing.


  1. 1.

    Niedernhofer, L. J. et al. Annu. Rev. Biochem. 87, 295–322 (2018).

    CAS  Article  Google Scholar 

  2. 2.

    Trifunovic, A. et al. Nature 429, 417–423 (2004).

    CAS  Article  Google Scholar 

  3. 3.

    Vermulst, M. et al. Nat. Genet. 39, 540–543 (2007).

    CAS  Article  Google Scholar 

  4. 4.

    Hämäläinen, R.H. et al. Nat. Metab. (2019).

  5. 5.

    López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Cell 153, 1194–1217 (2013).

    Article  Google Scholar 

  6. 6.

    Edifizi, D. et al. Cell Rep. 20, 2026–2043 (2017).

    CAS  Article  Google Scholar 

  7. 7.

    Behrens, A., van Deursen, J. M., Rudolph, K. L. & Schumacher, B. Nat. Cell Biol. 16, 201–207 (2014).

    CAS  Article  Google Scholar 

  8. 8.

    Shimizu, I., Yoshida, Y., Suda, M. & Minamino, T. Cell Metab. 20, 967–977 (2014).

    CAS  Article  Google Scholar 

  9. 9.

    Fang, E. F. et al. Trends Mol. Med. 23, 899–916 (2017).

    CAS  Article  Google Scholar 

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Correspondence to Björn Schumacher or Jan Vijg.

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Schumacher, B., Vijg, J. Age is in the nucleus. Nat Metab 1, 931–932 (2019).

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