Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Age is in the nucleus

Nuclear DNA damage has detrimental effects on cellular homoeostasis and accelerates the ageing process. A new study causally links error-prone mitochondrial replication to increased nuclear DNA damage, thus suggesting that the hallmarks of ageing are associated with nuclear genome instability, a potential unifying denominator in the ageing process.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Nuclear DNA damage integrates the multiple hallmarks of ageing.


  1. Niedernhofer, L. J. et al. Annu. Rev. Biochem. 87, 295–322 (2018).

    Article  CAS  Google Scholar 

  2. Trifunovic, A. et al. Nature 429, 417–423 (2004).

    Article  CAS  Google Scholar 

  3. Vermulst, M. et al. Nat. Genet. 39, 540–543 (2007).

    Article  CAS  Google Scholar 

  4. Hämäläinen, R.H. et al. Nat. Metab. (2019).

  5. López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Cell 153, 1194–1217 (2013).

    Article  Google Scholar 

  6. Edifizi, D. et al. Cell Rep. 20, 2026–2043 (2017).

    Article  CAS  Google Scholar 

  7. Behrens, A., van Deursen, J. M., Rudolph, K. L. & Schumacher, B. Nat. Cell Biol. 16, 201–207 (2014).

    Article  CAS  Google Scholar 

  8. Shimizu, I., Yoshida, Y., Suda, M. & Minamino, T. Cell Metab. 20, 967–977 (2014).

    Article  CAS  Google Scholar 

  9. Fang, E. F. et al. Trends Mol. Med. 23, 899–916 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Björn Schumacher or Jan Vijg.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schumacher, B., Vijg, J. Age is in the nucleus. Nat Metab 1, 931–932 (2019).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing