Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


Skeletal muscle inefficiency protects against obesity

Obesity is the result of an imbalance between caloric intake from the diet and energy expenditure. A new study provides evidence that alterations in calcium transport efficiency in muscle lead to an increased metabolic rate and protect mice against diet-induced obesity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: SERCA inefficiency promotes energy expenditure in skeletal muscle.


  1. Hruby, A. & Hu, F. B. Pharmacoeconomics 33, 673–689 (2015).

    Article  Google Scholar 

  2. Bal, N. C. et al. Nat. Med. 18, 1575–1579 (2012).

    Article  CAS  Google Scholar 

  3. Bombardier, E. et al. FASEB J. 27, 3871–3878 (2013).

    Article  CAS  Google Scholar 

  4. Verkerke, A. R. P. et al. Nat. Metab. (2019).

  5. Jacobs, R. L. et al. J. Biol. Chem. 285, 22403–22413 (2010).

    Article  CAS  Google Scholar 

  6. Tasseva, G. et al. Biochim. Biophys. Acta 1861, 119–129 (2016).

    Article  CAS  Google Scholar 

  7. Funai, K. et al. J. Clin. Invest. 123, 1229–1240 (2013).

    Article  CAS  Google Scholar 

  8. Maurya, S. K. et al. J. Biol. Chem. 290, 10840–10849 (2015).

    Article  CAS  Google Scholar 

  9. Maurya, S. K. et al. Cell Rep. 24, 2919–2931 (2018).

    Article  CAS  Google Scholar 

  10. Fu, S. et al. Nature 473, 528–531 (2011).

    Article  CAS  Google Scholar 

Download references


This work was supported in part by US National Institutes of Health grant R01 DK098240-01 and an American Diabetes Association- Basic Science Research Award (7-13-BS-131) to M.P.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Muthu Periasamy.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, F., Periasamy, M. Skeletal muscle inefficiency protects against obesity. Nat Metab 1, 849–850 (2019).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing