Losing control of nutrient sensing in the germinal centre drives lymphomagenesis

The gene encoding the RagC GTPase (RRAGC), an activator of a nutrient-sensing pathway that drives cellular anabolism, is mutated in 15% of follicular lymphoma cases. A new study provides evidence that RRAGC mutations promote lymphomagenesis by distorting the nutrient-dependent control of paracrine signals from the microenvironment, thus enhancing B-cell activation.

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Fig. 1: Model of the effects of RagC mutations on GC B-cell development and lymphomagenesis.


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Correspondence to Ulf Klein.

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Klein, U. Losing control of nutrient sensing in the germinal centre drives lymphomagenesis. Nat Metab 1, 750–751 (2019).

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