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CANCER METABOLISM

Losing control of nutrient sensing in the germinal centre drives lymphomagenesis

Nature Metabolism volume 1, pages 750–751 (2019)Cite this article

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The gene encoding the RagC GTPase (RRAGC), an activator of a nutrient-sensing pathway that drives cellular anabolism, is mutated in 15% of follicular lymphoma cases. A new study provides evidence that RRAGC mutations promote lymphomagenesis by distorting the nutrient-dependent control of paracrine signals from the microenvironment, thus enhancing B-cell activation.

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Fig. 1: Model of the effects of RagC mutations on GC B-cell development and lymphomagenesis.

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  1. Division of Haematology & Immunology, Leeds Institute of Medical Research at St. James’s, University of Leeds, Leeds, UK

    Ulf Klein

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  1. Ulf Klein
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Correspondence to Ulf Klein.

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The authors declare no competing interests.

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Klein, U. Losing control of nutrient sensing in the germinal centre drives lymphomagenesis. Nat Metab 1, 750–751 (2019). https://doi.org/10.1038/s42255-019-0103-2

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