ATHEROSCLEROSIS

Transforming endothelial cells in atherosclerosis

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Cells contributing to atherosclerotic disease are highly plastic and can shift their phenotype in a changing microenvironment. A study in Nature Metabolism now reveals that transforming growth factor-β (TGF-β) can transform endothelial cells into pro-inflammatory cells and that inhibition of TGF-β-receptor signalling in the endothelium can reverse atherosclerosis in mice.

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Fig. 1: Endothelial TGF-β signalling drives atherogenesis.

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Correspondence to Kathryn L. Howe or Jason E. Fish.

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The authors declare no competing interests.

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