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Transforming endothelial cells in atherosclerosis

Cells contributing to atherosclerotic disease are highly plastic and can shift their phenotype in a changing microenvironment. A study in Nature Metabolism now reveals that transforming growth factor-β (TGF-β) can transform endothelial cells into pro-inflammatory cells and that inhibition of TGF-β-receptor signalling in the endothelium can reverse atherosclerosis in mice.

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Fig. 1: Endothelial TGF-β signalling drives atherogenesis.


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Correspondence to Kathryn L. Howe or Jason E. Fish.

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Howe, K.L., Fish, J.E. Transforming endothelial cells in atherosclerosis. Nat Metab 1, 856–857 (2019).

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