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IMMUNOMETABOLISM

The metabolic tug of war between HIV and T cells

The loss of T cell immune function as a result of human immunodeficiency virus (HIV) infection leads to opportunistic infections and certain HIV-associated cancers. Two recent studies shed light on the complex immunometabolic changes during HIV infection and open the door to metabolic treatment options that could ultimately cure HIV.

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Fig. 1: Metabolic requirements for HIV infection and antiviral T cell immunity.

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Correspondence to Ramon I. Klein Geltink.

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Klein Geltink, R.I. The metabolic tug of war between HIV and T cells. Nat Metab 1, 653–655 (2019). https://doi.org/10.1038/s42255-019-0091-2

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