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Reply to: Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter

The Original Article was published on 12 July 2019

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Fig. 1: Analysis of NMN using HPLC and LC–MS/MS.
Fig. 2: Hypercarb HPLC chromatograms of NMN in extracts from control and FK866-treated NIH3T3 cells and mouse primary hepatocytes.


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Authors and Affiliations



S.I. and A.G. mainly wrote the correspondence. J.Y. conducted the experiments and analyses discussed in Fig. 1. A.G. performed the experiments and analyses discussed in Fig. 2. K.M., S.B., G.S., K.T., H.C.L., M.M. and Y.S. contributed to the preparation of the correspondence.

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Correspondence to Shin-ichiro Imai.

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Competing interests

A.G. and S.I. are inventors on a patent (PCT/US18/46233) about the Slc12a8 NMN transporter, whose applicant is Washington University; it has been licensed by Teijin Limited. The other authors declare no competing interests.

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Grozio, A., Mills, K., Yoshino, J. et al. Reply to: Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter. Nat Metab 1, 662–665 (2019).

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